论文部分内容阅读
为反映过敏性哮喘时小气道平滑肌反应性亢进与组胺H_1受体变化的关系,揭示哮喘发病机制,本研究采用豚鼠离体肺条功能实验法及肺组织冰冻切片H_1受体与~3H-吡拉明结合实验,观察了正常及过敏性哮喘豚鼠肺条对H_1受体激动剂组胺的反应性、最大收缩和pD_2值的变化;在H_1受体拮抗剂马来酸氯苯吡胺存在时pA_2值的变化以及~3H-吡拉明与H_1受体结合量的变化。结果表明:1.哮喘豚鼠肺条开始发生收缩所需组胺
To reflect the allergic asthma small airway smooth muscle hyperthyroidism and histamine H 1 receptor changes in the relationship revealed the pathogenesis of asthma in this study using guinea pig lung function tests and lung tissue frozen sections of H 1 receptor and 3H- In combination with piraein, the response, maximal contraction and pD_2 of H 1 receptor agonist histamine were observed in the lung strips of normal and allergic asthmatic guinea pigs. In the presence of H 1 receptor antagonist chlorpheniramine maleate, PA_2 changes and the binding of ~ 3H-pyrilamine to H_1 receptors. The results showed that: 1. Asthmatic guinea pig lung began to shrink the required histamine