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188Re标记锡硫混悬液经两步制备得到。先用188Re的高铼酸盐与疏代硫酸钠溶液在明胶及酸性条件下加入氯化亚锡得到酸性的188Re标记混悬液,然后调pH至中性而制得188Re标记锡硫混悬液。混悬液的颗粒度主要为2—5um,放化纯度大于95%,体内、体外稳定性良好。动物实验表明,该混悬液对荷人脑胶质瘤裸鼠的抑瘤率达90%。
The 188Re-labeled tin sulfur suspension was prepared in two steps. First with 188Re perrhenate and sodium thiosulfate solution in gelatin and acidic conditions by adding stannous chloride to obtain acidic 188Re labeled suspension, and then adjust the pH to neutral and 188Re labeled tin sulfur suspension . The particle size of the suspension is mainly 2-5um, radiochemical purity greater than 95%, in vivo and in vitro stability is good. Animal experiments show that the suspension of human glioma bearing tumor inhibition rate of 90%.