缺血性脑血管病(ischemic cerebrovasculardisease,ICVD)是脑血管疾病中最常见的一种,且有向年轻化发展的趋势。其对人们的威胁及危害也越来越严重,在死因排位中的位序不断前移,给国家及患者家庭带来了沉重的负担。发病后能否得到及时、合理的治疗是提高患者治愈率、降低病死率的关键。随着实验研究和临床研究的不断深入,可以证实急性局灶性脑缺血的病理生理变化,是由缺血引起能量耗竭、兴奋性氨基酸增加等多途径,致使细胞内 Ca~(2+)增加,再以瀑布式产生多种有毒物质如氧自由基、ONOO~-、炎性细胞因子 Ischemic cerebrovascular disease (ischemic cerebrovascular disease, ICVD) is the most common type of cerebrovascular disease, and there is a tendency to develop younger. Its threat and harm to people are also more and more serious. The continual advancement of the ranks in the cause of death places a heavy burden on the country and its families. After the onset of timely and reasonable treatment is to improve the cure rate of patients, reduce the key to mortality. With the deepening of experimental research and clinical research, we can confirm that the pathophysiological changes of acute focal cerebral ischemia are caused by many factors, such as energy depletion caused by ischemia, increased excitatory amino acids, Increase, then a waterfall produces a variety of toxic substances such as oxygen free radicals, ONOO ~ -, inflammatory cytokines