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A series of novel N-phenylbenzamide and N-phenylacetophenone compounds were synthesized and evaluated for their antiviral activity against HCV and EV71(strain SZ-98).The biological results showed that three compounds(23,25 and 41) exhibited considerable anti-HCV activity(IC50? 0.57–7.12 μmol/L) and several compounds(23,28,29,30,31 and 42) displayed potent activity against EV71 with the IC50 values lower than 5.00 μmol/L.The potency of compound 23(IC50? 0.57 μmol/L) was superior to that of reported compounds IMB-1f(IC50? 1.90 μmol/L) and IMB-1g(IC50? 1.00 μmol/L) as anti-HCV agents,and compound29 possessed the highest anti-EV71 activity,comparable to the comparator drug pirodavir.The efficacy in vivo and antiviral mechanism of these compounds warrant further investigations.
A series of novel N-phenylbenzamide and N-phenylacetophenone compounds were synthesized and evaluated for their antiviral activity against HCV and EV71 (strain SZ-98). The biological results showed that the three compounds (23,25 and 41) exhibit adequate anti-HCV activity (IC50 0.57-7.12 μmol / L) and several compounds (23,28,29,30,31 and 42) displayed potent activity against EV71 with the IC50 values lower than 5.00 μmol / L. potency of compound 23 0.57 μmol / L) was superior to that of reported compounds IMB-1f (IC50 -1.90 μmol / L) and IMB-1g (IC50 1.00 μmol / L) as anti-HCV agents, and compound 29 possessed the highest anti- EV71 activity, comparable to the comparator drug pirodavir. The efficacy in vivo and antiviral mechanism of these compounds warrant further investigations.