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目的研究多发性骨髓瘤(multiple myeloma,MM)患者中IL-6的表达水平,阐明其在MM肾损伤中的作用及临床意义。方法采用化学发光法对80例MM肾损伤患者(32例肾功能不全不可逆者,28例肾功能不全可逆者和20例肾功能正常者)以及40例健康体检者(正常对照组)的IL-6表达量进行检测并比较。结果 IL-6在肾功能不全不可逆者表达明显升高,与肾功能不全可逆者、MM肾功能正常者以及40例健康体检者IL-6表达比较差异有统计学意义(P<0.01);肾功能不全可逆者与正常对照组比较差异有统计学意义(P<0.05),肾功能不全可逆者与MM肾功能正常者比较,MM肾功能正常者与正常对照组IL-6表达比较差异无统计学意义(P>0.05);MM患者不同分期IL-6表达差异有统计学意义(P<0.01)。结论 IL-6检测可作为MM患者肾功能不全病变程度诊断指标,为临床治疗提供帮助。
Objective To study the expression of IL-6 in patients with multiple myeloma (MM) and to elucidate the role and clinical significance of IL-6 in MM. Methods The chemiluminescence method was used to detect IL-1β in 80 patients with MM kidney injury (32 cases of irreversible renal insufficiency, 28 cases of renal insufficiency and 20 cases of normal renal function) and 40 healthy subjects (normal control group) 6 expression levels were detected and compared. Results The expression of IL-6 was significantly increased in patients with irreversible renal insufficiency (P <0.01). The expression of IL-6 was significantly higher in patients with normal renal dysfunction, MM normal renal function and 40 healthy controls (P <0.01) Compared with normal control group, the difference was statistically significant (P <0.05), renal dysfunction and MM renal dysfunction were compared, MM renal function was normal and normal control group IL-6 expression was no statistical difference (P> 0.05). The difference of IL-6 expression in different stages of MM patients was statistically significant (P <0.01). Conclusion The detection of IL-6 can be used as a diagnostic indicator of the degree of renal dysfunction in patients with MM, providing clinical help.