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Objective:To determine the polymorphisms of Interleukin-10(IL-10)(-592,-1082) in pulmonary tuberculosis(PTB)with and without type 2 diabetes(T2D).Methods:We studied a Mexican mestizo population of 37 patients with TB in remission(TBr) and 40 with active pulmonary TB (PTB),21 patients with TB + T2D.47 blood donors accepted,and 13 healthy health-care workers with tuberculin skin lest positive.Determination of IL-10 polymorphisms was performed by real-lime Polymerase chain reaction.Results:IL-10-592C/A presented in a greater proportion in healthy individuals than in patients with type 2 diabetes and TB in a not quite significant statistically manner.IL-10-1082A/A presented more frequently in the group of patients with both diseases,not being statistically significant in comparison with the group of healthy subjects. Conclusions:This study describes two important new findings.First,it reveals that the IL-10 (-592 A/A and -592 C/C) polymorphisms were found in a greater proportion in a group of patients with T2D and TB than in healthy subjects.Second,the study provides evidence that the(-1082 G/G) polymorphism presented with greater frequency in healthy individuals than in patients with both ol these diseases.
Objective: To determine the polymorphisms of Interleukin-10 (IL-10) (- 592, -1082) in pulmonary tuberculosis (PTB) with and without type 2 diabetes (T2D). Methods: We studied a Mexican mestizo population of 37 patients with TB in remission (TBr) and 40 with active pulmonary TB (PTB), 21 patients with TB + T2D.47 blood donors accepted, and 13 healthy health-care workers with tuberculin skin lest positive. Determination of IL-10 polymorphisms was performed by Real-lime Polymerase chain reaction. Results: IL-10-592C / A presented in a greater proportion in healthy individuals than in patients with type 2 diabetes and TB in a not quite quite manner manner. IL-10-1082A / A presented more frequently in the group of patients with both diseases, not being statistically significant in comparison with the group of healthy subjects. Conclusions: This study describes two important new findings. First, it reveals that the IL-10 (-592 A / A and - 592 C / C) polymorphisms were found in a greater proportion in a group of patients with T2D and TB than in healthy subjects. Second, the study provides evidence that the (-1082 G / G) polymorphism presented with greater frequency in healthy individuals than in patients with both ol disease.