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目的:探讨女性老年人高血压病肾气亏虚证、肝火上炎证与性激素受体表达紊乱的关联性,从而为研究老年人高血压病肾气亏虚证、肝火上炎证证候表现的病理生理基础提供依据。方法:根据高血压诊断与分级标准、中医辨证标准选择了女性高血压病肾气亏虚证、肝火上炎证患者各20例和健康老年女性20例,应用流式细胞检测法检测受试者外周血中ER-β和AR的荧光强度。结果:女性老年人高血压患者的性激素受体数量处于一种低水平状态,可以作为诊断女性老年人高血压病的特异性指标;AR的下降幅度可以用来作为区分女性老年人高血压病肾气亏虚证和肝火上炎证的有效指标,且肾气亏虚证患者AR数量的下降幅度大于肝火上炎证患者。
OBJECTIVE: To investigate the association between the symptoms of kidney deficiency of qi and blood and the disturbance of the expression of sex hormone receptors in the elderly hypertensive patients with kidney-qi deficiency syndrome, Provide the basis for the pathophysiology. Methods: According to the standard of diagnosis and grading of hypertension, 20 cases of female patients with Hypertension with Deficiency of Kidney-Qi, 20 cases of Anhuo-Shang-Yan Syndrome and 20 healthy elderly women were selected according to TCM Syndrome Differentiation Criteria. Flow cytometry Fluorescence intensity of ER-β and AR in peripheral blood. Results: The number of sex hormone receptors in female elderly hypertensive patients was at a low level, which could be used as a specific index to diagnose hypertension in female elderly. The decline of AR could be used as a marker of hypertension in the elderly Qi deficiency syndrome and an effective indicator of inflammation of the liver, and the amount of AR deficiency patients with AR decline is greater than the number of patients with liver fire Shangyan.