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目的建立大鼠颈脊髓损伤后水钠代谢紊乱的动物模型。方法在预实验基础上选成年雌性Wistar大鼠45只,随机分为正常饲养无手术对照组(A组)15只,肠内营养乳剂(TP)喂养并行胃造瘘和颈后路椎旁肌剥离手术对照组(B组)15只,肠内营养乳剂喂养并行颈脊髓完全横断损伤及胃造瘘术、导尿术实验组(C组)15只,其中C组3只鼠术后死亡弃用,测量血钠、尿钠浓度及尿量。结果与B组相比,C组于手术4 d后均获得明显低钠血症(P<0.05)。A组和B、C组术前血钠浓度无明显差异(P>0.05)。结论大鼠颈脊髓完全损伤后引起低钠血症的发生,可以作为颈脊髓损伤并发低钠血症动物模型进行深入研究。
Objective To establish an animal model of water-sodium metabolism disorder after cervical spinal cord injury in rats. Methods Forty-five adult female Wistar rats were randomly divided into normal control group (A group), fed with enteral nutrition emulsion (TP) and gastric peristalsis 15 rats in the control group (group B) were enrolled in this study. Fifteen rabbits in the control group (group B) were fed with enteral nutrition emulsion and completely transected injury of the cervical spinal cord and gastrostomy. Catfish catheterization group (C) Use, measurement of serum sodium, urinary sodium concentration and urine output. Results Compared with group B, group C had obvious hyponatremia after 4 days of operation (P <0.05). There was no significant difference in preoperative serum sodium between group A and B, C (P> 0.05). Conclusion The occurrence of hyponatremia after complete injury of cervical spinal cord in rats may be used as an animal model of cervical spinal cord injury complicated with hyponatremia.