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目的:分析比较甲苯胺红不加热血清试验法(TRUST)和明胶颗粒凝集法(TPPA)两种梅毒血清学试验检测方法的临床诊断价值。方法:对来自贵阳市疾病预防控制中心495例梅毒患者的血清进行TRUST与TPPA两种试验检测,比较两种梅毒血清筛选试验方法,观察其检测结果。结果:495份血清标本中,TRUST法检测结果164例阳性,阳性率为33.13%,滴度≥1:32有6例,为1.21%;TPPA法检测结果417例阳性,阳性率84.24%;TEUST和TPPA法同时检测结果162例阳性,占32.73%,TRUST检查阴性而TPPA法检测结果170例阳性,占34.34%。两种方法的阳性率差异有统计学意义(p<0.05)。结论:为了减少漏检,提高诊断率,应综合使用TRUST与TPPA两种梅毒血清学试验检测方法。
OBJECTIVE: To analyze the clinical diagnostic value of two serological test methods of syphilis, TRUST and TPPA. Methods: The serum of 495 syphilis patients from Guiyang Municipal Center for Disease Control and Prevention was tested by TRUST and TPPA. The test results of two kinds of syphilis serum screening tests were compared. Results: Of the 495 serum samples, TRUST assay was positive in 164 cases and the positive rate was 33.13%. Titers ≥1: 32 in 6 cases were 1.21%. The results of TPPA assay were positive in 417 cases and the positive rate was 84.24%. TEUST 162 cases were positive with TPPA test, accounting for 32.73%. TRUST test was negative and TPPA test result was 170 cases, accounting for 34.34%. The positive rates of the two methods were statistically different (p <0.05). Conclusion: In order to reduce the missed inspection and increase the diagnostic rate, two syphilis serological test methods, TRUST and TPPA, should be used in combination.