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目的评价盐酸贝尼地平治疗原发性高血压病患者的疗效和安全性。方法用多中心随机单盲平行对照试验方法。贝尼地平(试验组)112例,氨氯地平(对照组)105例。结果治疗8周后,2组血压均有明显下降,与用药前比较差异均有统计学意义(P<0.001)。总有效率为贝尼地平77.68%,氨氯地平83.81%,2组间比较差异无统计学意义(P>0.05)。药物不良反应发生率为贝尼地平42.86%,氨氯地平41.60%,2组比较差异无统计学意义(P>0.05)。结论盐酸贝尼地平治疗原发性高血压安全、有效。
Objective To evaluate the efficacy and safety of benidipine hydrochloride in the treatment of patients with essential hypertension. Methods A multicenter randomized single-blind parallel controlled trial was used. Benidipine (test group) 112 cases, amlodipine (control group) 105 cases. Results After 8 weeks of treatment, the blood pressure in both groups decreased significantly, with statistical significance (P <0.001). The total effective rate was 77.68% for benidipine and 83.81% for amlodipine. There was no significant difference between the two groups (P> 0.05). Adverse drug reactions occurred in 42.86% of benidipine and 41.60% of amlodipine, there was no significant difference between the two groups (P> 0.05). Conclusion Benidipine hydrochloride is safe and effective in treating essential hypertension.