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目的探讨在晨峰高血压患者的治疗中应用替米沙坦联合苯磺酸氨氯地平片的效果。方法 92例晨峰高血压患者,采用计算机表法分为实验组和参照组,各46例。参照组行替米沙坦片(美卡素)治疗,实验组行替米沙坦片联合苯磺酸氨氯地平片治疗。比较两组临床疗效。结果实验组治疗后白天平均收缩压为(133.6±9.2)mm Hg(1 mm Hg=0.133 k Pa),优于参照组的(150.1±9.3)mm Hg(P<0.05);实验组舒张压、清晨收缩压差值均优于参照组(P<0.05)。经1~2年的随访比较,两组患者的收缩压、舒张压、不良反应比较差异均有统计学意义(P<0.05)。结论将替米沙坦联合苯磺酸氨氯地平片应用于晨峰高血压患者的治疗中,有显著的治疗效果,对于临床研究具有重要意义。
Objective To investigate the effect of telmisartan combined with amlodipine besylate in the treatment of patients with morning-peak hypertension. Methods 92 cases of morning peak hypertension patients were divided into experimental group and reference group by computerized table, each of 46 cases. The reference group, telmisartan tablets (mecamycins) treatment, the experimental group telmisartan tablets combined with amlodipine besylate tablets treatment. The clinical efficacy of the two groups were compared. Results The mean daytime systolic blood pressure in the experimental group was (133.6 ± 9.2) mm Hg (1 mm Hg = 0.133 kPa), which was significantly higher than that of the reference group (150.1 ± 9.3 mm Hg, P <0.05) Early systolic blood pressure values were better than the reference group (P <0.05). After 1 to 2 years of follow-up comparison, the two groups of patients with systolic blood pressure, diastolic blood pressure, adverse reactions were statistically significant differences (P <0.05). Conclusion The combination of telmisartan and amlodipine besylate in the treatment of patients with morning-peak hypertension has significant therapeutic effect, which is of great significance for clinical research.