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目的:观察大肠小扁平腺瘤p53、p21基因的表达,探讨小扁平腺辔与息肉样腺瘤生物学行为的不同及其与大肠癌的天系。方法:利用免疫组化法研究50例小扁平腺瘤(A组)和30例息肉样腺瘤(B组以及20例正常大肠黏膜(C组)的p53、P21基因表达情况。结果:p53、p21在A、B、C三组中阳性率分别为58％、56％;33.3％、36.7%;5％、10％。p53阳性率三组间差异有显著性(P<0.05)。p21阳性率:A、B组分别与C组有差异显著性(P<0.05);A组高于B组,但卡方检验P>0.05,无统计学差异;A组进一步与B组中直径<1.0cm的腺瘤的p21阳性率(30％)比较,差异有显著性(P<0.05)。结论:大肠小扁平腺瘤p53、p21基因的异常表达提示小扁平腺瘤的生物学行为与息肉样腺瘤有差别,可能更易于恶变。
OBJECTIVE: To observe the expression of p53 and p21 genes in small flat adenoma of the large intestine and to explore the difference of biological behavior between the flattened gonadal pleomorphic polyps and the polypoid adenomas and their relationship with the colorectal cancer. Methods: The expressions of p53 and P21 genes in 50 cases of small flat adenoma (group A) and 30 cases of polypoid adenoma (group B and 20 cases of normal colorectal mucosa (group C) were studied by immunohistochemistry.Results: The positive rates of p21 in groups A, B and C were 58%, 56%, 33.3%, 36.7%, 5% and 10%, respectively. There was a significant difference between the three groups (P <0.05) There was no significant difference between group A and group B (P <0.05); group A was higher than group B, but there was no significant difference between group A and group C cm (P <0.05) .Conclusion: The abnormal expression of p53 and p21 in small flat adenoma of small intestine suggests that the biological behavior of small flat adenoma is similar to that of polypoid Adenomas are different and may be more susceptible to malignant transformation.