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肝昏迷又称肝性脑病,是由于肝功能严重障碍,不能消除血液中有毒代谢产物;或由于形成门体静脉短路使血液中有毒物质经侧枝循环绕过肝脏而进入中枢神经系统,引起脑代谢紊乱,从而发生以意识障碍和昏迷为主的一系列神经精神症状。它是肝病的一个重危并发症。大多数预后不良。关于肝昏迷发病机理的研究,近年来虽有不少进展,但仍未最终阐明。总的说来,倾向于由蛋白质代谢的多方面紊乱所引起。本文概述肝昏迷发病机理有关学说的生化基础。
Hepatic coma, also known as hepatic encephalopathy, is due to severe liver dysfunction, can not eliminate toxic metabolites in the blood; or due to the formation of portal vein short circuit so that toxic substances in the blood through the collaterals bypass the liver and enter the central nervous system, causing brain metabolism Disorder, resulting in a series of symptoms of neuropsychiatric disorders and coma. It is a serious complication of liver disease. Most of the prognosis is poor. On the pathogenesis of hepatic coma, although in recent years a lot of progress, but has not yet been finalized. In general, tend to be caused by various aspects of protein metabolism disorders. This article outlines the biochemical basis of the theory of the pathogenesis of hepatic coma.