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目的：探讨补体C3、C4在急性心肌梗死中的变化趋势，并进一步探讨其临床意义。方法前瞻性收集2015年1月~2015年6月于北京友谊医院住院的急性心肌梗死（acute myocardial infarction，AMI）患者150例。纳入本课题研究的患者在入院后第1、3、7天检测血清补体C3、C4水平，同时检测肌酸激酶同工酶（creatine kinase-MB，CK-MB）、心肌肌钙蛋白T（cardiac troponin T，TnT）指标。按心功能状况分为心功能KillipⅠ-Ⅱ级组、心功能KillipⅢ-Ⅳ级组。结果血清补体C3、C4在心肌梗死患者中普遍升高，随着天数增加而升高，高峰出现在第3天，并于第7天回落；血清补体C3、C4与CK-MB、TnT呈正性相关（P<0.01）；与心功能KillipⅠ-Ⅱ级组比较，心功能KillipⅢ-Ⅳ级组C3、C4值明显升高，差异有统计学意义（P<0.05）。结论补体C3、C4对急性心肌梗死的诊断有一定的参考价值，其意义与CK-MB、TnT相似；补体C3、C4水平与急性心肌梗死后患者的心功能有一定的关系，其升高者心脏功能往往较差。“,”Objective To investigate the clinical significance of complenents C3 and C4 in diagnosis of acute myocardiac infarction (AMC). Methods 150 AMI patients, 104 males and 46 females, 92 with heart function at KillipⅠ~Ⅱlevel and 58 with heart function at KillipⅢ~Ⅳ level, underwent peripheral venous blood collection at days 1, 3, and 7 after admission to test the serum levels of suplements C3 and C4, creatine kinase-MB (CK-MB), and cardiac troponin T (TnT). Receiver operating characteristic curve (ROC) was used to evaluate the values of C3 and C4 in predicting the change of heart function in AMI patients. Results The serum levesl of C3 and C4 increased after admission and peaked at day 3. The C3 and C4 levels were positively correlated with the levels of CK-MB and TnT(all P<0.01). The serum levels of C3 and C4 of the Killip Ⅲ~Ⅳ group were both significantly higher than those of the Killip Ⅰ~Ⅱ group (both P<0.05). Conclusion The serum levels of C3 and C4 have a certain reference value in diagnosis of AMI with the significances similar to those of CK-MB and TnT.