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目的 :观察不同年龄在腰麻下手术病人静脉内注射安定后血药浓度 (Cp)与镇静深度的关系。方法 :在 17例腰麻下手术病人中 ,测定安定的Cp和脑电双频谱指数 (BIS) ,并分析两者与镇静深度的关系。结果 :镇静评分为 0、1、2、3、4、5时安定Cp分别是 75 2± 3 5 9、65 2± 2 69、5 5 6± 193、4 88± 15 1、3 88± 13 2和 3 12± 12 8ng/ml。静脉给予安定0 2mg/kg后约 5 0分钟病人镇静评分降至 5分清醒水平。在同一镇静评分的情况下年龄较大的病人所测得Cp较低 ,两者呈负相关。结论 :BIS与镇静评分有较好相关 ,提示老年病人安定用量宜酌减。
OBJECTIVE: To observe the relationship between serum concentration (Cp) and the sedation depth after intravenous injection of diazepam at different ages under surgical treatment of spinal anesthesia. Methods: In 17 patients undergoing surgery under spinal anesthesia, the stability of Cp and bispectral index (BIS) were measured, and the relationship between them and the depth of sedation was analyzed. Results: When the sedation scores were 0, 1, 2, 3, 4 and 5 diastolic blood pressure was 75 2 ± 3 5 9, 65 2 ± 2 69, 55 6 ± 193, 488 ± 15 1, 388 ± 13 2 and 3 12 ± 12 8 ng / ml. Sedation 0 2mg / kg intravenously after about 50 minutes patient sedation score dropped to 5 points awake level. Older patients under the same sedation score had a lower Cp and a negative correlation between the two. Conclusion: BIS has a good correlation with sedation scores, suggesting that the elderly patients should reduce the amount of stability.