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目的探讨一氧化氮(NO)在口腔黏膜癌变过程中的意义。方法采用免疫组织化学法对10例人口腔鳞状细胞癌、10例上皮单纯增生、50例上皮异常增生及10例正常口腔黏膜标本中诱导型一氧化氮合酶(iNOS)的表达。结果口腔鳞状细胞癌组中有8例iNOS表达阳性(80%),与正常黏膜组及单纯上皮增生组相比,差异有统计学意义(P<0.01);上皮异常增生组中有38例iNOS表达阳性(76%),与正常黏膜组及单纯上皮增生组相比有显著性差异(P<0.01);而上皮异常增生组与口腔鳞状细胞癌组相比,差异无统计学意义(P>0.05)。结论由iNOS诱导产生的NO可能在口腔鳞癌的发生、发展中起着重要作用。
Objective To investigate the significance of nitric oxide (NO) in the carcinogenesis of oral mucosa. Methods Immunohistochemistry was used to detect the expression of inducible nitric oxide synthase (iNOS) in 10 cases of human oral squamous cell carcinoma, 10 cases of epithelial hyperplasia, 50 cases of epithelial dysplasia and 10 cases of normal oral mucosa. Results The expression of iNOS in oral squamous cell carcinoma group was significantly higher than that in normal mucosa group and simple epithelial hyperplasia group (P <0.01). There were 38 cases in epithelial dysplasia group The positive expression of iNOS (76%) was significantly higher than that in normal mucosa group and simple epithelial hyperplasia group (P <0.01). However, there was no significant difference between the epithelial dysplasia group and oral squamous cell carcinoma group P> 0.05). Conclusion NO induced by iNOS may play an important role in the occurrence and development of oral squamous cell carcinoma.