论文部分内容阅读
目的:研究鼻咽癌中T淋巴细胞共刺激分子B7-H3表达与临床病理因素的相关性。方法:采用免疫组化SP法检测B7-H3在56例鼻咽癌标本中的表达情况,分析其与肿瘤类型,大小,淋巴结转移情况的关系。结果:在鼻咽非角化型分化性癌和鼻咽非角化型未分化性癌中B7-H3阳性表达率差别无统计学意义(P>0.05),有颈部淋巴结转移和无颈部淋巴结转移的鼻咽癌标本中B7-H3的阳性表达率差别有统计学意义(P<0.05)。结论:B7-H3的表达可能与鼻咽癌的转移和进展有关,与鼻咽癌组织学类型无关。
Objective: To study the correlation between the expression of costimulatory molecule B7-H3 of T lymphocyte and clinicopathological factors in nasopharyngeal carcinoma. Methods: Immunohistochemical SP method was used to detect the expression of B7-H3 in 56 cases of nasopharyngeal carcinoma, and its relationship with tumor type, size and lymph node metastasis was analyzed. Results: The positive rate of B7-H3 in nasopharyngeal non-keratinizing differentiated carcinoma and nasopharyngeal non-keratinizing undifferentiated carcinoma was not significantly different (P> 0.05), with lymph node metastasis and no neck The positive rate of B7-H3 expression in lymph node metastatic NPC specimens was significantly different (P <0.05). Conclusion: The expression of B7-H3 may be related to the metastasis and progression of nasopharyngeal carcinoma, which is not related to the histological type of NPC.