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目的探讨糖尿病患者CEA水平与RAGE的相关性。方法收集24例住院糖尿病患者(根据强化治疗分为DM强化治疗前组和DM强化治疗后组)和24例健康对照者(对照组)。检查入组患者的CEA、Hb A1c和RAGE等相关指标,比较3组CEA和RAGE水平并分别计算其相关性。结果糖尿病患者强化治疗前CEA和RAGE均显著高于强化治疗后和健康对照者,差异有统计学意义(P<0.05);强化治疗后DM组CEA和RAGE显著高于健康对照者,差异有统计学意义(P<0.05);强化治疗前后Hb A1c、RAGE与CEA呈正相关(r值分别为0.709、0.776,P<0.05);而强化治疗后的RAGE与Hb A1c无相关性(r=0.092,P>0.05)。结论糖尿病患者的CEA和RAGE水平呈正相关,RAGE可能是糖尿病患者CEA升高的机制之一。
Objective To investigate the correlation between CEA level and RAGE in diabetic patients. Methods Twenty-four inpatients with diabetes mellitus (DM-treated group and DM-treated group) and 24 healthy controls (control group) were enrolled in this study. CEA, Hb A1c, RAGE and other related indicators of the patients were examined. The levels of CEA and RAGE in the three groups were compared and their correlations were calculated. Results The levels of CEA and RAGE in patients with DM before treatment were significantly higher than those in patients after intensive treatment and those in healthy controls (P <0.05). CEA and RAGE in DM patients after intensive treatment were significantly higher than those in healthy controls (R = 0.709, 0.766, P <0.05). However, there was no correlation between RAGE and Hb A1c after intensive treatment (r = 0.092, P> 0.05). Conclusion There is a positive correlation between CEA and RAGE in diabetic patients, and RAGE may be one of the mechanisms of CEA in diabetic patients.