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目的研究慢性乙型肝炎青年患者的器质性勃起功能障碍(ED)和代谢综合征(MS)之间的关系,探讨影响慢性乙肝青年男性患者器质性ED患者代谢综合征的主要危险因素。方法收集121例慢性乙肝青年男性患者,对所有患者进行数据记录统计及国际勃起功能5项评分(IIEF-5),并参照MS诊断标准将患者分为ED组和非ED组,对比两组患有MS比例,并对两组病患的年龄等临床指标进行对比并分析两组之间的差异,按照IIEF-5项评分对所有ED病患进行病情严重程度分级,对MS组与非MS组患者病情严重程度进行对比,结合MS危险因素与IIEF-5评分,进一步去评估MS危险因素与IIEF-5评分两者之间是否具有相关性。结果在所有慢性乙型肝炎患者中,ED组内患有MS 47例,占ED组患者77.0%;非ED组内患有MS 28例,占非ED组患者46.7%;ED组内患有MS的比例显著高于非ED组内患有MS比例(P<0.05)。ED组患者体重、体重指数(BMI)、腰围明显高于非ED组(P<0.05),ED组患者总胆固醇、甘油三脂、低密度脂蛋白水平高于非ED组(P<0.05),而高密度脂蛋白水平显著低于非ED组患者(P<0.05),年龄、身高等其他指标两组差异无统计学意义(P>0.05)。无MS危险因素组IIEF-5评分显著高于伴有2个以上MS危险因素组患者(P<0.05),并且随MS危险因素数量逐步增加,IIEF-5评分逐渐下降。结论慢性乙型肝炎青年男性器质性ED患者较非ED患者MS患病率显著增高,中心性肥胖、高脂血症可能是构成慢性乙型肝炎青年男性患者器质性ED的主要危险因素。
Objective To study the relationship between organic erectile dysfunction (ED) and metabolic syndrome (MS) in young patients with chronic hepatitis B and to explore the main risk factors affecting metabolic syndrome in young patients with chronic hepatitis B. Methods A total of 121 chronic hepatitis B (CHB) male patients were enrolled in this study. Data recording statistics and five international erectile dysfunction scores (IIEF-5) were collected. All patients were divided into ED group and non-ED group according to MS diagnostic criteria. MS ratio and the age of two groups of patients and other clinical indicators were compared and analyzed the difference between the two groups, according to IIEF-5 score of all patients with ED severity of disease classification, MS group and non-MS group The severity of the disease was compared with MS risk factors and IIEF-5 scores to further assess whether there is a correlation between MS risk factors and IIEF-5 scores. Results In all patients with chronic hepatitis B, there were 47 MS patients in ED group, accounting for 77.0% of ED patients; 28 MS patients in ED group, accounting for 46.7% of non-ED patients; MS patients in ED group had MS Was significantly higher than that in non-ED patients (P <0.05). The body weight, body mass index (BMI) and waist circumference in ED group were significantly higher than those in non-ED group (P <0.05). The levels of total cholesterol, triglyceride and low density lipoprotein in ED group were significantly higher than those in non-ED group While the level of HDL was significantly lower than that of non-ED patients (P <0.05). There was no significant difference in age, height and other indicators between the two groups (P> 0.05). The score of IIEF-5 in MS without risk factor group was significantly higher than that in patients with MS risk factor of more than 2 (P <0.05), and gradually decreased with the increase of MS risk factors. Conclusion The prevalence of MS was significantly higher in non-ED patients with chronic hepatitis B than in non-ED patients. The central obesity and hyperlipidemia may be the major risk factors for organic ED in young male patients with chronic hepatitis B infection.