目的:探讨免疫抑制剂他克莫司和环孢素与肾移植术后孕妇妊娠期高血压疾病发生的关系。方法:共搜集了32例肾移植术后妊娠的患者并根据应用的免疫抑制剂类型分为他克莫司组和环孢素组,每组各16例,比较从肾移植术后到围产期间的血压、尿蛋白水平、血肌酐值、空腹血糖值和妊娠结局。结果:他克莫司组在妊娠早期和妊娠晚期的尿蛋白水平低于环孢素组,差异有极显著统计学意义(P≤0.001);环孢素组的8例患者在妊娠晚期尿蛋白>3 000 mg/L,而他克莫司组仅出现3例24 h尿蛋白>3 000 mg/L;他克莫司组的妊娠期舒张压显著低于环孢素组,差异有统计学意义(P=0.008);他克莫司组和环孢素组的妊娠期高血压发病率分别为18.8%和34.4%,先兆子痫的发病率分别为9.4%和25.0%,差异均有统计学意义。两组空腹血糖值及妊娠结局组间无统计学差异。结论:应用他克莫司孕妇的妊娠高血压疾病和先兆子痫发病率低于应用环孢素的孕妇。提示他克莫司是肾移植术后孕妇的优选免疫抑制剂。 Objective: To investigate the relationship between immunosuppressive agents, tacrolimus and cyclosporine, in the development of gestational hypertension in pregnant women after renal transplantation. Methods: A total of 32 patients with pregnancy after renal transplantation were collected and divided into tacrolimus group and cyclosporine group according to the type of immunosuppressive agents used, 16 cases in each group. Blood pressure, urinary protein levels, serum creatinine, fasting blood glucose, and pregnancy outcomes during the study. Results: Urinary protein levels in early and late pregnancy in tacrolimus group were lower than those in cyclosporine group (P≤0.001). In the cyclosporine group, urinary protein > 3 000 mg / L, while the tacrolimus group only 3 cases of 24 h urinary protein> 3000 mg / L; tacrolimus group gestational diastolic pressure was significantly lower than the cyclosporine group, the difference was statistically significant (P = 0.008). The incidences of gestational hypertension in the tacrolimus group and cyclosporine group were 18.8% and 34.4% respectively, and the incidences of preeclampsia were 9.4% and 25.0%, respectively, with statistical differences Significance of learning. There was no significant difference between the two groups in fasting blood glucose and pregnancy outcomes. CONCLUSIONS: The incidence of pregnancy-induced hypertension and pre-eclampsia in pregnant women receiving tacrolimus is lower than in pregnant women receiving cyclosporine. Tip Tacrolimus is a preferred immunosuppressive agent for pregnant women after renal transplantation.