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目的 探讨子宫肿瘤与氧自由基的关系。方法 测定子宫良、恶性肿瘤患者瘤组织、同源瘤旁组织及对照组血清ＳＯＤ、ＧＳＨ－ ＰＸ 和ＬＰＯ 的含量。结果 子宫良性和恶性肿瘤组织中ＳＯＤ、ＧＳＨ－ Ｐｘ／ＬＰＯ 比值均明显低于同源瘤旁组织；恶性肿瘤组织中ＧＳＨ－ Ｐｘ 显著低于瘤旁组织，而ＬＰＯ增高（ Ｐ均＜ ０．００１） ，并且ＧＳＨ－ Ｐｘ／ＬＰＯ比率亦显著低于良性肿瘤组（ Ｐ＜０．００１） ；子宫恶性肿瘤组血清ＧＳＨ－ Ｐｘ／ＬＰＯ 比率明显低于良性肿瘤组和对照组（ Ｐ＜ ０ ．０１） 。结论 机体组织中ＳＯＤ、ＧＳＨ－Ｐｘ 和ＬＰＯ含量变化与子宫肿瘤的发生、发展及恶变密切关联，血清抗氧化酶水平尚不足于恶性肿瘤的早期诊断，但ＧＳＨ－ Ｐｘ／ＬＰＯ比率对子宫肿瘤的良、恶性鉴别具有重要的临床价值。
Objective To investigate the relationship between uterine tumors and oxygen free radicals. Methods The levels of SOD, GSH-PX and LPO in serum of benign and malignant uterine tumor tissues, para-tumorous tissues and control group were determined. Results The ratio of SOD, GSH-Px / LPO in benign and malignant uterus tissues was significantly lower than that in the adjacent tissues of the same tumor. The GSH-Px in malignant tumors was significantly lower than that in the adjacent tissues and LPO was higher (all P <0.001 ), And the ratio of GSH-Px / LPO was significantly lower than that of benign tumor (P <0.001). The ratio of GSH-Px / LPO in malignant uterus was significantly lower than that in benign tumor and control ). Conclusion The changes of SOD, GSH-Px and LPO contents in body tissues are closely related to the occurrence, development and malignant transformation of uterine tumors. The levels of serum antioxidant enzymes are not yet enough for the early diagnosis of malignant tumors. However, the ratio of GSH-Px / Good and malignant identification has important clinical value.