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目的:调查围绝经期妇女血清雌二醇水平变化和其他相关生化指标的变化特点及其与衰老的关系。方法:应用放射免疫分析方法、酶动力学方法和邻苯三酚自氧化法分别测定573例围绝经期妇女血清雌二醇、卵泡刺激素(FSH)、超氧化物歧化酶(SOD)和碱性磷酸酶(ALP)水平。结果:围绝经期妇女雌二醇水平显著低于绝经前妇女(P<0.01)。围绝经期妇女ALP水平显著高于绝经前妇女(P<0.05)。SOD随增龄而逐渐下降。围绝经期妇女血清雌二醇水平与雌二醇/FSH呈明显负相关,与ALP和SOD相关性较好。结论:围绝经期妇女测定ALP能反映骨生成情况,测定血清雌二醇和SOD水平变化可反映组织老化及细胞生物膜的损伤变化过程,且与人类衰老关系密切。
Objective: To investigate the changes of serum estradiol level and other related biochemical parameters in perimenopausal women and its relationship with aging. Methods: The levels of serum estradiol, follicle stimulating hormone (FSH), superoxide dismutase (SOD), and alkali in 573 perimenopausal women were determined by radioimmunoassay, enzyme kinetic and pyrogallol autoxidation respectively. Phosphatase (ALP) levels. Results: Estradiol levels in perimenopausal women were significantly lower than those in premenopausal women (P <0.01). Perimenopausal women ALP levels were significantly higher than pre-menopausal women (P lt; 0.05). SOD gradually decreased with age. Serum estradiol levels in peri-menopausal women were significantly negatively correlated with estradiol / FSH and correlated well with ALP and SOD. CONCLUSION: Peri-menopausal women can detect the formation of osteoporosis by measuring the level of ALP, and the changes of serum estradiol and SOD levels can reflect the changes of tissue aging and cell biofilm damage, and are closely related to human aging.