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目的通过比较合并与未合并浅部真菌感染的变态反应性皮肤病对常用变应原的敏感性,综合从皮肤或指(趾)甲中分离出的菌种情况,评估浅部真菌感染在变态反应性皮肤病的病因学中的作用。方法受试者包括353例慢性荨麻疹、湿疹及特应性皮炎患者。通过真菌直接镜检法将受试者分为两组。实验组:变态反应性皮肤病合并浅部真菌感染组(n=173);对照组:变态反应性皮肤病无浅部真菌感染组(n=180)。对所有实验组及对照组受试者进行9种真菌变应原和9种非真菌变应原皮内试验。实验组患者进一步进行真菌培养以鉴定菌种。结果慢性荨麻疹患者实验组须发癣菌、新月弯孢霉,特异青霉、烟曲霉变应原阳性率显著高于对照组(P<0.05),慢性湿疹患者实验组须发癣菌变应原阳性率显著高于对照组(P<0.001)。慢性湿疹、荨麻疹患者其他真菌变应原及粉尘螨、屋尘螨等非真菌变应原阳性率比较差异均无统计学意义(P>0.05)。134例患者皮肤或指(趾)甲分离鉴定主要为红色毛癣菌(52.86%)、须癣毛癣菌(14.18%)、絮状表皮癣菌(5.22%)、白念珠菌(6.72%),实验组须发癣菌变应原阳性率及皮肤分离皮肤癣菌阳性率比较差异无统计学意义(P>0.05)。结论实验结果表明,须发癣菌变应原阳性的慢性荨麻疹、湿疹患者往往合并皮肤癣菌感染,皮肤癣菌感染可能在部分慢性荨麻疹、湿疹的病因学中起重要作用。
Objective To assess the susceptibility of superficial fungal infections in metamorphosis by comparing susceptibility to common allergens for allergic skin diseases with or without superficial mycotic infections and by isolating species isolated from the skin or nails The role of reactive dermatosis in etiology. Methods Subjects included 353 patients with chronic urticaria, eczema and atopic dermatitis. Subjects were divided into two groups by fungal direct microscopy. Experimental group: allergic dermatosis with superficial fungal infection (n = 173); control group: allergic dermatosis without superficial fungal infection (n = 180). Nine fungal allergens and nine non-fungal allergens were tested intradermally in all experimental and control subjects. Patients in the experimental group were further subjected to fungal culture to identify the species. Results The positive rate of Trichophyton mentagrophytes, Curvularia lunata, Penicillium cholerae and Aspergillus fumigatus in the experimental group was significantly higher than that in the control group (P <0.05). The Trichophyton mentagrophytes should be in the experimental group with chronic eczema The positive rate was significantly higher than the control group (P <0.001). Chronic eczema, urticaria patients with other fungal allergens and dust mite, house dust mites and other non-fungal allergens were no significant difference (P> 0.05). 134 cases of skin or toenail were isolated and identified as Trichophyton rubrum (52.86%), Trichophyton mentagrophytes (14.18%), Epidermophyton floccosum (5.22%) and Candida albicans (6.72% , The experimental group Trichophyton mentagrophytes allergen positive rate and skin dermatophytes isolates were no significant difference (P> 0.05). Conclusions The experimental results show that chronic urticaria and eczema patients with Trichophyton mentagrophytes allergens are often associated with dermatophytes infection. Dermatophytes infection may play an important role in the etiology of some chronic urticaria and eczema.