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门冬酰胺酶是治疗急性淋巴细胞性白血病的一种有效药物。动物实验表明,它有抑制免疫的作用,对体液免疫、细胞免疫以及对器官移植的排斥反应都能抑制。此酶还是一种强抗原,能引起严重过敏反应,甚至过敏性休克。据统计,其发生率约为16％。如何早期发现对门冬酰胺酶的免疫反应,及时采取措施防止过敏性休克的发生,这是值得研究的课题。
Asparaginase is an effective drug for the treatment of acute lymphocytic leukemia. Animal experiments show that it has the role of immune suppression, humoral immunity, cellular immunity and rejection of organ transplantation can inhibit. This enzyme is also a strong antigen, can cause severe allergic reactions, and even anaphylactic shock. According to statistics, the incidence rate is about 16%. How to detect the immune response to asparaginase at an early stage and take timely measures to prevent the occurrence of anaphylactic shock is a subject worth studying.