目的　MODS是腹部外科疾病患者死亡的最直接、最重要的原因之一。本研究探索有效合理的综合临床救治方法。方法　①短程大剂量山莨菪碱和地塞米松联用的综合治疗方法 ;②“分阶段代谢营养支持”治疗 ;③采用自制的“解毒固本冲剂”配合治疗 ;④针对“炎性介质、细菌、内外毒素”等 8个方面 ,提出了多环节兼顾和并治的 12条综合治疗具体措施 ;⑤生长激素和生长抑素治疗等 ;⑥手术治疗等。结果　按KnausW .A教授MODS的诊断标准 ,118例中共死亡 5 9例 ,病死率为 5 0 0 0 %。其中应用传统常规疗法的 87例 ,死亡 49例 ,病死率为 5 6 32 %。采用综合救治新策略的 31例中 ,共死亡 10例 ,病死率为 32 2 5 %。结论　MODS病因复杂 ,治疗困难 ,死亡率高 ,采用综合救治新策略疗法能降低MODS的死亡率 Purpose MODS is one of the most direct and important causes of death in patients with abdominal surgical diseases. This study explores effective and comprehensive clinical treatment. Methods ① The combined treatment of short-term high-dose anisodamine and dexamethasone; ② The treatment of “staged metabolism and nutrient support”; ③ The treatment of “Detoxifying Guben Granule” , Internal and external toxins, "and other eight aspects, put forward a multi-link and concurrent treatment of 12 comprehensive treatment of specific measures; ⑤ growth hormone and somatostatin treatment; ⑥ surgical treatment. Results According to Professor Knaus W.A’s diagnostic criteria of MODS, 118 deaths were caused by 59 deaths and the case fatality rate was 500%. Among them, 87 cases were treated with conventional therapy, 49 cases died, with a case fatality rate of 56.23%. Of the 31 patients who adopted the new strategy of comprehensive treatment, 10 died and the case fatality rate was 32 2 5%. Conclusions The causes of MODS are complicated, the treatment is difficult, and the mortality rate is high. Comprehensive treatment of new strategies can reduce the mortality of MODS