目的:分析急性重症创伤患者凝血功能障碍与病情严重程度及预后的关系。方法:选取本院2018年7月至2019年9月接收的急性重症创伤患者74例，按照损伤严重评分（ISS）>25分、>16分且≤25分、≤16分划分成极危重组、危重组、不危重组，并结合预后情况划分成死亡组与生存组，所有患者入院24 h内均需进行凝血功能检测，对比各组患者凝血功能，回顾分析患者凝血功能障碍与病情严重程度、预后的关系。结果:极危重组、危重组、不危重组患者FIB、PT、D-D、PLT、血栓弹力图K值、MA值、R值、α角度比较差异具有统计学意义，死亡组和生存组患者FIB、PT、D-D、PLT、血栓弹力图K值、MA值、R值、α角度比较差异具有统计学意义，患者血栓弹力图K值与FIB、PLT呈负相关性，与PT、D-D呈正相关性；MA值与FIB、PLT呈正相关性，与PT、APTT、D-D呈负相关性；R值与PT、APTT、D-D、PLT呈正相关性；α角度与FIB、PLT呈正相关性，与PT呈负相关性。结论:急性重症创伤患者凝血功能障碍与病情严重程度及预后存在明显的关系，通过凝血功能检查、血栓弹力图能帮助判断病情严重程度，评估预后效果。“,”Objective:To analyze the relationship between coagulation dysfunction and severity and prognosis in patients with acute severe trauma.Methods:Seventy-four patients with acute severe trauma treated at our hospital from July 2018 to September 2019 were included. According to the injury severity score (ISS) > 25 points, > 16 points and ≤25 points, and ≤16 points, patients were divided into the extremely critical group, critical group, and non-critical group. And according to the prognosis, the patients were divided into the death and survival groups. All patients had the blood coagulation function test within 24 h of admission. The coagulation function of patients in each group was compared, and the relationship between coagulation dysfunction and the severity and prognosis of patients were retrospectively analyzed.Results:There were significant differences in FIB, PT, D-D, PLT, K value, Ma value, R value and α angle among the extremely critical group, critical group, and non-critical group. FIB, PT, APTT, D-D, PLT and K value of thromboelastogram were negatively correlated with FIB and PLT in the death group and survival group, while FIB, PT, APTT, D-D, PLT and K value of thromboelastogram were positively correlated with PT and DD. Ma value was positively correlated with FIB and PLT, negatively correlated with PT and APTT, R value was positively correlated with PT, APTT, D-D and PLT, and α angle was positively correlated with FIB and PLT, and negatively correlated with PT ( n P < 0.05).n Conclusions:Coagulation function examination and thromboelastogram can help to determine the severity of the disease and evaluate the prognosis.