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目的 口服透膜吸收枸椽酸芬太尼制剂 ( OTFC)是通过口腔粘膜吸收的芬太尼的固体形态。临床多次应用 OTFC治疗癌痛的应用价值需进一步评价。本研究的目的是验证多次应用不会改变 OTFC药物动力学的假设。方法 12例健康成人自愿者分别静脉应用芬太尼( 15 μg/ kg)或 OTFC(三次
OBJECTIVE Oral Permembrane Absorption The fentanyl citrate preparation (OTFC) is a solid form of fentanyl that is absorbed through the oral mucosa. The clinical application of multiple applications of OTFC in the treatment of cancer pain needs further evaluation. The purpose of this study was to verify the hypothesis that multiple applications will not alter the pharmacokinetics of OTFC. Methods Twelve healthy volunteers were given intravenous fentanyl (15 μg / kg) or OTFC (three times