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目的加强药物不良反应监护,让医师和药师认识到药学监护的重要性,保证临床用药安全。方法介绍1例81岁肺部感染女性患者,因使用哌拉西林他唑巴坦4.5 g静滴(q8 h)抗感染治疗14 d后,导致其血小板严重减少,双侧大腿内侧出现大片淤血斑。临床药师在治疗过程中及时提出停用哌拉西林他唑巴坦换用其他抗菌药物的合理性建议。结果停用哌拉西林他唑巴坦后,血小板恢复正常,淤血斑完全消失。结论临床药师参与临床药物治疗实践,有利于协助医生提高药物治疗水平及保证患者的用药安全。
Objective To strengthen the monitoring of adverse drug reactions, allowing physicians and pharmacists to recognize the importance of pharmacy monitoring and ensure the safety of clinical medication. Methods A case of 81-year-old female with pulmonary infection was treated with piperacillin-tazobactam at a dose of 4.5 g intravenously (q8 h) for 14 days, resulting in a severe reduction of platelets and massive congestion of blood on the inside of both thighs . Clinical pharmacists in the course of treatment promptly discontinued piperacillin and tazobactam switch to other rational use of antimicrobial drugs recommendations. Results After discontinuation of piperacillin and tazobactam, platelet returned to normal and congestion spots completely disappeared. Conclusion Clinical pharmacists participate in the practice of clinical drug treatment, which helps to help doctors improve the level of drug treatment and ensure the safety of patients.