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以酚酞作为光谱探针 ,采用紫外 可见光谱滴定法测定了 β 环糊精 (β CD)、单 (6 氧 α 麦芽糖 ) β 环糊精 (6 G2 β CD )和单 [2 氧 (2 羟丙基 ) ] β 环糊精 (2 HP β CD )在 2 5℃时 ,pH =10 5缓冲液中(0 0 2 5mol/L)与几种脂肪族手性客体分子所形成超分子配合物的稳定常数 .结果表明 ,多种弱相互作用力协同作用于环糊精的配位过程 ,主 客体间的尺寸匹配决定所形成配合物的稳定性 .环糊精衍生物的取代基影响主体的配位能力 ,对于尺寸较小的客体分子配位能力的大小一般为 2 HP β CD >β CD >6 G2 β CD .另一方面 ,3种环糊精主体化合物对一些脂肪族客体分子也表现出一定的手性识别能力 ,对 (+ ) 异构体给出相对较强的键合能力 ,其中 ,2 HP β CD对 (+ ) /(- ) 樟脑的配位选择性为 1 2 5 .
Phenolphthalein was used as a spectral probe to determine the β CD, 6 G2 β CD and 2 O 2 hydroxyproline titration with UV-Vis spectrophotometry. (2 HP β CD) at 25 ℃, pH = 10 5 buffer (0 0 2 5mol / L) with several aliphatic chiral guest molecules formed by supramolecular complexes Stable constants.The results show that a variety of weak interactions act synergistically on the coordination process of cyclodextrins and the size matching between host and guest determines the stability of the complex formed.The substituents of cyclodextrin derivatives affect the distribution of the host The ability of a molecule to bind to a guest of smaller size is typically 2 HP β CD> β CD> 6 G2 β CD. On the other hand, the three cyclodextrin host compounds also show some aliphatic guest molecules A certain chiral recognition ability gave relatively strong bonding ability to the (+) isomer. Among them, the coordination selectivity of (+) / (-) camphor for 2 HP β CD was 125.