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理想的心肌损伤生化标志物应具有高度临床敏感和特异性,心肌损伤后出现早、持续时间长,且检测方便。在心肌酶学检查中,以往认为只有CK-MB和LDH1的敏感性和特异性相对较高,但上述心肌酶的测定在临床应用时仍有许多不足之处,如存在诊断特异性差,早期诊断(6小时内)敏感性不高,诊断窗口时间短,对于冠状动脉栓塞导致的心肌微梗死不能诊断等。因此国内外一些学者都在努力寻找一些能够克服上述不足的新的生化标志物。自1987年英国Cummins等
Ideal biochemical markers of myocardial injury should be highly clinically sensitive and specific, early after myocardial injury, long duration, and easy to test. Myocardial enzymology in the past that only the sensitivity and specificity of CK-MB and LDH1 relatively high, but the determination of myocardial enzymes in clinical application there are still many deficiencies, such as the presence of poor diagnostic specificity, early diagnosis (6 hours) is not high sensitivity, the diagnostic window is short, can not be diagnosed for myocardial infarction caused by coronary embolism. Therefore, some domestic and foreign scholars are trying to find some new biochemical markers that can overcome the above shortcomings. Since 1987 British Cummins et al