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动脉粥样硬化(Atherosclerosis,As)被认为是一种慢性炎症性疾病。急性时相血清淀粉样蛋白A(acute serum amyloid A,A-SAA)可以通过诱发炎症反应、干扰脂质转运和降低动脉粥样硬化斑块的稳定性,从而参与动脉粥样硬化的发生和发展。本文就A-SAA导致As的内在机制进行综述。
Atherosclerosis (As) is considered a chronic inflammatory disease. Acute phase serum Amyloid A (A-SAA) can participate in the occurrence and development of atherosclerosis by inducing inflammation, interfering with lipid transport and reducing the stability of atherosclerotic plaque . This article reviews the underlying mechanisms by which A-SAA leads to As.