Several new transition metal complexes using Schiff base containing pyridine and amide moieties (N, N’-bis(- salicylaliminoethyl)-2, 6-pyridinedicarboxylic amide, H4L) as the ligand have been prepared. Their compositions and structures are corroborated by elemental analysis, IR, UV, 1H NMR, DTA-TG and molar conductivity data. Their anti-bacterial activities have been studied by microcalorimetry. The result shows that the ligand and all com-plexes are potential anti-bacteria reagent and their inhibitory capacities are concentration-depended. The Mn com-plex has the strongest inhibitory capacity. Several new transition metal complexes using Schiff base containing pyridine and amide moieties (N, N’-bis (- salicylaliminoethyl) -2, 6-pyridinedicarboxylic amide, H4L) as the ligand have been prepared. Their compositions and structures are corroborated by elemental analysis Their anti-bacterial activities have been studied by microcalorimetry. The results shows that the ligand and all com-plexes are potential anti-bacteria reagent and their inhibitory capacities are concentration -depended. The Mn com-plex has the strongest inhibitory capacity.