干扰素(interferon,IF)是长野小岛于1954年发现,1957年Isaacs 等命名的。干扰素的发现,推动了病毒增殖机理、细胞病变的诱发机理、病毒感染的发病、免疫机理等的研究,同时对病毒性疾病的认识也更加深入。基于上述研究,干扰素已试用于各科临床。现就儿科范围内的一些问题分述如下。一、IF 的临床应用 Interferon (IF) was discovered in 1954 by Nagano Kojima and named by Isaacs in 1957. The discovery of interferon has promoted research on the mechanism of viral proliferation, the mechanism of the induction of cytopathies, the onset of viral infections, and the immune mechanism. At the same time, it has deeper understanding of viral diseases. Based on the above studies, interferons have been tried in various clinical settings. Some of the issues in the pediatrics are now described below. I. Clinical application of IF