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目的探讨RRM1在宫颈癌组织中的表达水平与宫颈癌发生、发展的关系。方法应用免疫组织化学方法检测RRM1蛋白在80例宫颈癌组织、30例宫颈上皮内瘤变和20例正常宫颈组织中的表达。结果 RRM1在正常宫颈组织、宫颈上皮内瘤变和宫颈癌组织中都有不同程度的表达,但宫颈癌组织中RRM1的表达(93.7%,75/80)明显高于宫颈内瘤变(46.7%,14/30)和正常宫颈组织(10.0%,2/20),且宫颈癌组织分化程度越低则RRM1的阳性率越高,表达强度越强(P<0.01);RRM1的表达与宫颈癌临床分期无关(P>0.05);不同组织类型的宫颈癌RRM1的表达差异无统计学意义(P>0.05);RRM1的阳性表达与有无淋巴结转移无关(P>0.05)。结论 RRM1在宫颈癌组织中的表达与宫颈癌组织分化的高低有关。RRM1在宫颈癌的发生发展中起重要作用,有望成为宫颈癌新的早期诊断指标。
Objective To investigate the relationship between the expression of RRM1 in cervical cancer and the occurrence and development of cervical cancer. Methods The expression of RRM1 protein was detected by immunohistochemistry in 80 cases of cervical cancer, 30 cases of cervical intraepithelial neoplasia and 20 cases of normal cervical tissue. Results The expression of RRM1 in normal cervical tissues, cervical intraepithelial neoplasia and cervical cancer tissues was significantly higher than that in cervical cancer tissues (93.7%, 75/80) , 14/30) and normal cervical tissue (10.0%, 2/20) respectively. The lower the degree of differentiation was, the higher the positive rate of RRM1 was and the stronger the expression was (P <0.01) (P> 0.05). There was no significant difference in the expression of RRM1 in different types of cervical cancer (P> 0.05). The positive expression of RRM1 was not associated with lymph node metastasis (P> 0.05). Conclusions The expression of RRM1 in cervical cancer is related to the differentiation of cervical cancer. RRM1 plays an important role in the occurrence and development of cervical cancer and is expected to become a new early diagnostic indicator of cervical cancer.