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目的:观察清热解毒凉血方灌肠联合思密达治疗小儿感染性腹泻的疗效。方法:将162例感染性腹泻患儿随机分为中药组、联合组和对照组。中药组64例采用清热解毒凉血方灌肠治疗;联合组68例在中药组治疗基础上口服思密达治疗;对照组30例仅口服思密达。3组均观察治疗第3天、第5天疗效,并追踪随访至15天。结果:治疗第3天,总有效率中药组为71.7%,联合组为91.9%,对照组为50.0%。治疗第5天,总有效率中药组为93.3%,联合组为100%,对照组为71.4%。两个时间段各组总体比较,差异有显著性意义(P<0.05),中药组、联合组临床疗效均优于对照组(P<0.05),联合组优于中药组(P<0.05)。两个不同感染类型腹泻止泻时间各组总体比较,差异有显著性意义(P<0.05),中药组、联合组止泻时间均短于对照组(P<0.05),联合组短于中药组(P<0.05)。各组病毒性腹泻止泻时间均长于细菌性腹泻(P<0.05)。结论:清热解毒凉血方灌肠能提高思密达治疗感染性腹泻患儿的疗效,缩短止泻时间,值得推广应用。
Objective: To observe the effect of Qingre Jiedu Shuangxue Fang enema combined with Smecta on children with infectious diarrhea. Methods: 162 cases of children with infectious diarrhea were randomly divided into traditional Chinese medicine group, combination group and control group. Sixty-four patients in the traditional Chinese medicine group were treated with Qingrejiedu and Liangxue Fang enema. 68 cases in the combined group were treated with oral metsemin on the basis of the treatment of traditional Chinese medicine group. Only 30 cases in the control group were given oral metmyme. Three groups were observed on the third and fifth days of treatment efficacy, and follow-up to 15 days. Results: On the third day of treatment, the total effective rate was 71.7% in the traditional Chinese medicine group, 91.9% in the combined group and 50.0% in the control group. On the fifth day of treatment, the total effective rate was 93.3% in the traditional Chinese medicine group, 100% in the combined group and 71.4% in the control group. Compared with the control group (P <0.05), the clinical curative effect of the traditional Chinese medicine group and the combined group was better than that of the control group (P <0.05). There was significant difference between the two groups (P <0.05). The diarrhea time of two different infection types in each group showed significant difference (P <0.05), while the diarrhea time in both Chinese medicine group and combined group was shorter than that in control group (P <0.05) (P <0.05). The diarrhea time of each group was longer than that of bacterial diarrhea (P <0.05). Conclusion: Qingrejiedu Liangxuefang enema can improve the efficacy of Smectite in children with infectious diarrhea, shorten the time of antidiarrheal, which is worth popularizing and applying.