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目的探讨二巯基丙磺酸钠(Na-DMPS)治疗毒鼠强中毒血清毒鼠强浓度的动态变化及临床疗效。方法将我院2001年11月2002年10月给予常规治疗的30例急性毒鼠强中毒患者作对照组;将2002年11月至2003年10月收治的24例作治疗组。治疗组除常规治疗外,另加 Na-DMPS。观察血清毒鼠强变化、抽搐次数、控制抽搐时间,并进行比较。结果治疗组与对照组治疗1、2周后血清毒鼠强浓度、抽搐次数和控制抽搐时间差异均有显著性(P<0.05)。结论 Na-DMPS 对急性毒鼠强中毒疗效明显,可降低血清毒鼠强浓度,从而缩短抽搐时间,降低抽搐强度,延长抽搐间隔时间,减轻器官功能损伤,缩短治疗时间,提高治愈率。
Objective To investigate the dynamic changes and clinical effects of sodium dimercaptopropane sulfonate (Na-DMPS) in the treatment of strong tetramine poisoned rats. Methods Thirty patients with acute tetramine poisoning who were routinely treated in our hospital from November 2001 to October 2002 were selected as the control group. Twenty-four patients treated from November 2002 to October 2003 were selected as the treatment group. The treatment group in addition to conventional treatment, plus Na-DMPS. Serum tetramine observed strong changes, the number of convulsions, control of convulsions time, and compared. Results After treatment for 1 and 2 weeks, the concentrations of sevoflurane, the number of seizures and the time of controlling seizures in treatment group and control group were significantly different (P <0.05). Conclusion Na-DMPS has obvious curative effect on acute tetramine poisoning in rats and can reduce the concentration of serum tetramine in rats. It can shorten the time of convulsions, reduce the twitch intensity, prolong the intervals of convulsions, reduce the organ damage, shorten the treatment time and improve the cure rate.