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目的观察原发性肝癌（ＰＨＣ）患者血清甲状腺激素的变化。方法应用放射免疫法（ＲＩＡ）检测２４例ＰＨＣ患者的血清Ｔ３，Ｔ４，ＴＳＨ和ｒＴ３，并以２４例健康成人作对照。结果ＰＨＣ组血清Ｔ３为１．６０±０．１４ｎｍｏｌ／Ｌ，而对照组为２．３７±０．０８ｎｍｏｌ／Ｌ（Ｐ＜０．００１）。ＰＨＣ切除组血清Ｔ３，Ｔ４和ｒＴ３分别为１．９４±０．１６ｎｍｏｌ／Ｌ，１３４．３４±１１．４９ｎｍｏｌ／Ｌ和２．６１±０．３９；而ＰＣＨ未切除组分别为１．２２±０．１７ｎｍｏｌ／Ｌ（Ｐ＜０．０５），１０４．０１±７．２４ｎｍｏｌ／Ｌ（Ｐ＜０．０５）和１．３５±０．３６（Ｐ＜０．０５）。结论ＰＨＣ患者血清Ｔ３降低，晚期患者出现血清Ｔ４降低和Ｔ３／ｒＴ３比值降低。
Objective To observe the changes of serum thyroid hormone in patients with primary liver cancer (PHC). Methods The serum T3, T4, TSH and rT3 were detected by radioimmunoassay (RIA) in 24 patients with PHC, and 24 healthy adults were used as controls. Results Serum T3 in PHC group was 1.60±0.14 nmol/L, while that in control group was 2.37±0.08 nmol/L (P<0.001). Serum T3, T4, and rT3 in the PHC resection group were 1.94±0.16 nmol/L, 134.34±11.49 nmol/L, and 2.61±0.39, respectively; while those in the PCH unexcision group were 1.22±1. 0.17 nmol/L (P<0.05), 104.01±7.24 nmol/L (P<0.05) and 1.35±0.36 (P<0.05). Conclusions Serum T3 levels decrease in patients with PHC, and serum T4 decreases and T3/rT3 ratio decreases in advanced patients.