Angew.Chem.Int.Ed.2016,55,1479~1483近年来,烯烃的官能团化三氟甲基化反应己取得重要进展,然而由于二氟甲基化试剂的缺乏,烯烃的官能团化二氟甲基化反应研究较少.[Ph_3PCF_2Br]Br是一种含氟季鏻盐,1973年Burton教授小组发现该试剂可由廉价易得的Ph_3P和CF_2Br_2在温和反应条件下以定量收率制备.几十年来[Ph_3PCF_2Br]Br一直作为二氟卡宾的来源应用于含氟化 Angew.Chem.Int.Ed.2016,55,1479 ~ 1483 In recent years, significant progress has been made in the functional trifluoromethylation of olefins. However, due to the lack of difluoromethylation reagents, the functionalized difluoro Methylation is less studied. [Ph_3PCF_2Br] Br is a fluorinated quaternary phosphonium salt. In 1973, Professor Burton’s team found that this reagent can be prepared in mild yield from inexpensive and readily available Ph_3P and CF_2Br_2 under mild reaction conditions. [Ph_3PCF_2Br] Br has been used as a source of difluorocarbene for fluorinated