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目的探讨肿瘤标志物CA125、CA153、CA724联合检测对卵巢恶性肿瘤的诊断价值。方法采用电化学发光法测定94例卵巢恶性肿瘤、55例卵巢良性肿瘤和20例健康妇女血清中CA125、CA153、CA724的水平。结果卵巢恶性肿瘤组患者血清CA125、CA153、CA724的水平显著高于卵巢良性肿瘤组和健康体检组(P<0.05),其中卵巢良性肿瘤组CA125水平高于健康体检组(P<0.05),CA153、CA724的水平与健康体检组无统计学差异(P>0.05)。血清CA125、CA153、CA724三项联合检测的灵敏度为84%,特异性为98.2%。结论联合检测CA125、CA153、CA724对卵巢恶性肿瘤的诊断和鉴别有重要意义。
Objective To investigate the diagnostic value of combined detection of tumor markers CA125, CA153 and CA724 in ovarian cancer. Methods The serum levels of CA125, CA153 and CA724 in 94 cases of ovarian cancer, 55 cases of ovarian benign tumor and 20 healthy women were determined by the method of electrochemiluminescence. Results The serum levels of CA125, CA153 and CA724 in patients with ovarian cancer were significantly higher than those in benign ovarian tumors and healthy controls (P <0.05). The serum levels of CA125 in benign ovarian tumors were significantly higher than those in healthy controls (P <0.05) There was no significant difference between CA724 level and healthy group (P> 0.05). The combined detection of serum CA125, CA153 and CA724 had a sensitivity of 84% and a specificity of 98.2%. Conclusions Combined detection of CA125, CA153 and CA724 is of great significance in the diagnosis and differential diagnosis of ovarian cancer.