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目的研究射干提取物中鸢尾苷及鸢尾黄素在大鼠体内的药动学。方法Wistar大鼠一次性ig给予相当于32倍临床等效剂量即10.8 g/kg射干提取物(每1 g提取物相当于5 g生药量),采用高效液相色谱法对血浆中鸢尾苷和鸢尾黄素进行定量测定,应用DAS软件计算主要药动学参数。结果鸢尾苷及鸢尾黄素在大鼠体内的药时过程符合二室模型,tmax均为1.5 h,Cmax分别为0.89、3.35μg/mL,AUC0-t分别为0.983、19.769 mg.L-1.h,AUC(0-∞)分别为1.034、23.927 mg.L-1.h;鸢尾苷及鸢尾黄素的t1/2分别为1.05、8.863 h。结论鸢尾黄素与鸢尾苷的达峰时间相同,但鸢尾黄素的消除半衰期比鸢尾苷消除半衰期长,说明鸢尾黄素在体内的药效有可能发挥得更持久。
Aim To study the pharmacokinetics of tectorigenin and tectorigenin in pericarp extract of rats. Methods Wistar rats were given ig with the equivalent of 32 times the clinical equivalent dose of 10.8 g / kg per day (equivalent to 5 g of crude drug per 1 g of extract) ig using high performance liquid chromatography (HPLC) The iris was quantitated and the main pharmacokinetic parameters were calculated using DAS software. Results The time courses of tectorigen and tectorigenin in rats were in accordance with the two-compartment model. The tmax was 1.5 h, the Cmax was 0.89 and 3.35 μg / mL respectively, and the AUC0-t were 0.983 and 19.769 mg.L-1, respectively. h and AUC (0-∞) were 1.034,23.927 mg.L-1.h respectively. The t1 / 2 values of tectorigen and tectorigenin were 1.05 and 8.863 h, respectively. Conclusion The peak time of tectorigenin and tectorigenin was the same, but the half-life of tectorihin was longer than that of tebufenoside. This indicated that the efficacy of tectorigenin in vivo might be more durable.