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反义核酸技术从分子水平破坏靶基因 ,已用于多种抗病毒的试验。我们以人工合成的硫代反义寡核苷酸研究针对ＨＢＶ不同区段反义寡核苷酸ＨＢＶ的抑制作用 ,从中筛选了效果最好的针对ＨＢＶｐｒｅＳ2的反义序列 (ａｓ ｐｒｅＳ2 )。为进一步探讨ａｓ ｐｒｅＳ2在肝癌治疗中的应用
Antisense nucleic acid technology destroys target genes at a molecular level and has been used in a variety of antiviral assays. Using synthetic antisense oligonucleotides, we investigated the inhibitory effect of different antisense oligonucleotides (HBV) against different regions of HBV. The best antisense sequence against HBVpreS2 (as preS2) was screened out. To further explore the as preS2 in the treatment of liver cancer