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应用冻融循环和辐射交联技术，制备了含有醋酸氨苄磺胺的增强的聚氧化乙烯共聚水凝胶膜，并对其理化性能和药物释放进行了研究。实验结果显示，与未经冻融循环处理的聚氧化乙烯共聚水凝胶膜比较，增强的聚氧化乙烯共聚水凝胶膜的抗张强度明显增加（p＜0．01），凝胶分数和断裂伸长率亦稍有增加，表明冻融循环处理可明显地改善该膜的机械性能，使该膜作为伤口敷料具有理想的柔韧性、交联度和伸缩性。溶胀度研究显示，该水凝胶膜的平衡水含量明显降低（p＜0．01），表明该膜在冷冻时发生了有意义的结构重组，结构的密度增加导致机械强度的增加。应用40kGy的电子束照射形成的聚氧化乙烯共聚水凝胶膜的抗张强度最高。在冻融前掺入醋酸氨苄磺胺的聚氧化乙烯共聚水凝胶膜用于释放研究，其药物释放持续7d，释放曲线符合药物的扩散性模型。
The freeze-thaw cycle and radiation cross-linking technique were used to prepare enhanced polyoxyethylene co-polymer hydrogel films containing ampicillin acetate, and its physicochemical properties and drug release were studied. The experimental results showed that the tensile strength of the poly (ethylene oxide) co-polymer hydrogel film increased significantly (p <0.01) compared with that of the non-freeze-thaw cycle polyoxyethylene copolymer hydrogel film. The gel fraction and The elongation at break also increased slightly, indicating that freeze-thaw cycle treatment can significantly improve the mechanical properties of the film, making the film as ideal for wound dressings with excellent flexibility, degree of crosslinking and flexibility. The swelling degree study shows that the equilibrium water content of the hydrogel film is significantly reduced (p <0.01), indicating that the membrane undergoes significant structural reorganization upon freezing, with an increase in the density of the structure leading to an increase in the mechanical strength. Tensile strength of the poly (ethylene oxide) co-polymer hydrogel film formed by irradiation with 40 kGy electron beam is the highest. Polyethylene oxide hydrogel films coated with ampicillin acetate before freeze-thaw were used for release studies. The drug release lasted for 7 days and the release curve was consistent with the drug diffusion model.