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本文报告WR_(33063)(菲甲醇衍生物)与硫酸奎宁治疗恶性疟的效果比较。在泰国东北部疟疾流行区收治51例男性恶性疟患者,其中25例用WR_(33063)治疗,26例用硫酸奎宁治疗。剂量为WR_(33063)每8小时600毫克(3只胶囊),每天1.8克,连服6天,硫酸奎宁为每8小时肠溶片2片(基质540毫克),每天1.95克,连服6天。全部病例均送药看服,如在半小时内呕吐则重新给药。在住院治疗期间,每天至少观察2次,记录症状和体征,并取末梢血液作原虫计数,每6小时量体温一次。于出院后第14、21和28天随访观察。结果:WR_(33063)组治疗25例患者中23例治愈,硫酸奎宁组治疗22例中21例治
This article reports the efficacy of WR 33066 (phenanthrene alcohol derivative) and quinine sulphate in the treatment of P. falciparum. Fifty-one patients with malaria were treated in the malaria-endemic area of northeastern Thailand, 25 of whom were treated with WR 33066 and 26 were treated with quinine sulfate. The dosage was 600 mg (8 capsules) per 8 hours at WR 33063, 1.8 g daily for 6 days. Quinine sulphate was 2 tablets (base 540 mg) per 8 h, 1.95 g daily, 6 days. All cases were sent to see the service, such as vomiting within half an hour to re-dosing. During hospitalization, observe at least twice a day, record the symptoms and signs, and take peripheral blood for protozoa count, body temperature once every 6 hours. Follow-up was observed on days 14, 21 and 28 after discharge. Results: In WR_ (33063) group, 23 of 25 patients were cured, 21 of 22 patients treated with quinine sulfate