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近10多年来,由于世界上不少国家对头孢菌素的结构改造进行了大量工作,研制出许多新品种。在临床上广泛应用,有许多感染性疾病得到控制。但事物都是一分为二的,由于一些头孢菌素长期使用,各种耐药菌株逐年增多,特别是大肠杆菌和肺炎杆菌的耐药性更为多见。另外,第一、二代头孢菌素抗菌谱不广,对某些阴性细菌不敏感。解决上述问题已成为临床医生的迫切愿望。第三代头孢菌素克服了上述问题。不过第三代头孢菌素虽然优点多,例如抗菌谱比第一、二代头孢菌素更广,有更强的抗菌活性,对
In the past 10 years, many countries in the world have done a lot of work on the structural transformation of cephalosporins and developed many new varieties. Widely used in clinical practice, there are many infectious diseases under control. But things are divided into two, due to the long-term use of some cephalosporins, a variety of resistant strains increased year by year, especially E. coli and Klebsiella pneumoniae resistance is more common. In addition, the first and second generation cephalosporins antibacterial spectrum is not wide, not sensitive to some negative bacteria. To solve these problems has become an urgent desire of clinicians. The third generation cephalosporins overcome the above problems. However, although the third-generation cephalosporins and more advantages, such as the antibacterial spectrum than the first and second generation cephalosporins broader, stronger antibacterial activity,