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目的:探究A型行为(TABP)与多囊卵巢综合征(PCOS)患者临床特征的相关性及对PCOS患者生存质量的影响。方法:对218名女性进行前瞻性研究,对照组(正常女性)94例,观察组(PCOS组)124例。所有对象均填写TABP量表(TABPQ)及中华生存质量量表。各组再根据TABPQ得分分为A组与非A组。检测早卵泡期生殖内分泌激素水平及糖脂代谢指标,比较各组间各项指标的差异。运用逐步回归分析,探究TABP与PCOS患者临床特征的相关性。结果:1 TABP在PCOS组与对照组之间的分布没有统计学差异(P>0.05);2PCOS组形神维度、喜、怒评分均显著低于对照组(P<0.05);3 A组七情维度及其包括的喜、怒、忧悲、惊恐评分均显著低于非A组(P<0.05);4A组患者发生肥胖及痤疮的几率大于非A组(P<0.05),在性激素、糖脂代谢水平及多毛、黑棘皮发生率方面组间无统计学差异(P>0.05);5多元线性回归分析提示TABP评分与Ferriman-Gallwey(F-G)多毛评分呈正相关。结论:TABP可降低PCOS患者的生存质量,加重肥胖、多毛及痤疮程度,但并不影响PCOS患者的生殖内分泌激素及糖脂代谢水平。适当的心理指导对PCOS的治疗是必要的。
Objective: To investigate the relationship between type A behavior (TABP) and clinical features of patients with polycystic ovary syndrome (PCOS) and its impact on the quality of life in patients with PCOS. Methods: A prospective study of 218 women was conducted, 94 in the control group (normal women) and 124 in the observation group (PCOS group). All subjects were filled in TABP Scale (TABPQ) and China Quality of Life Scale. Each group was divided into A group and non-A group according to TABPQ score. Detection of early follicular reproductive endocrine hormone levels and glucose and lipid metabolism indicators, the differences between the various indicators. Stepwise regression analysis was used to explore the correlation between TABP and clinical features of patients with PCOS. Results: There was no significant difference in the distribution of TABP between the PCOS group and the control group (P> 0.05); 2PCOS group was significantly lower than the control group (P <0.05) (P <0.05). The incidences of obesity and acne in group 4A were significantly higher than those in group A (P <0.05). In sex hormones, There was no significant difference in the level of glucose and lipid metabolism and the incidence of hirsutism and acanthosis (P> 0.05) .5 Multiple linear regression analysis showed that TABP score was positively correlated with Ferriman-Gallwey (FG) hirsutism score. Conclusion: TABP can reduce the quality of life of patients with PCOS, increase the degree of obesity, hirsutism and acne, but does not affect the reproductive endocrine hormones and glucose and lipid metabolism in patients with PCOS. Proper psychological guidance is necessary for the treatment of PCOS.