目的探讨46例青年人大肠癌的临床特点及诊治。方法回顾性分析安阳市安钢职工总医院2000年10月-2009年10月收治的46例青年人大肠癌患者临床资料。结果青年人大肠癌发病率男性高于女性,癌肿以直肠和乙状结肠为多,误诊率达63%。本组均行手术治疗,行左半结肠切除5例,乙状结肠切除12例,右半结肠切除7例,横结肠切除术4例,姑息性切除结肠造瘘4例,行Miles手术9例,Dixon手术5例。组织病理学类型以低分化腺癌、黏液细胞癌为多,本组患者术后均定期化疗。均获随访,半年内死亡者10人,存活半年至1年者22人,存活2年以上者8人,3年以上者5人,4年以上者1人。多数病程短,临床症状无特异性,治疗效果较差。结论青年人大肠癌发病比率高,病种恶性程度高,临床误诊误治率高,手术根治率和5年生存率低。提高青年人大肠癌生存率的关键在于及早诊断,只有早期发现、早期诊断、及时合理的治疗,才能提高疗效。 Objective To investigate the clinical features and diagnosis and treatment of 46 cases of young people with colorectal cancer. Methods The clinical data of 46 young patients with colorectal cancer who were treated in Anyang Iron and Steel General Hospital of General Staff from October 2000 to October 2009 were retrospectively analyzed. Results The incidence rate of colorectal cancer in young men was higher than that in women. The number of cancers in rectum and sigmoid colon was much, and the misdiagnosis rate was 63%. This group of patients underwent surgical treatment of the left half of the colon resection in 5 cases, sigmoid colon resection in 12 cases, right colon resection in 7 cases, transverse colon resection in 4 cases, palliative resection of colostomy in 4 cases, Miles surgery in 9 cases, Dixon surgery 5 cases. Histopathological types of poorly differentiated adenocarcinoma, mucinous cell carcinoma and more, the group of patients after regular chemotherapy. All of them were followed up. There were 10 deaths within 6 months, 22 survived from 6 months to 1 year, 8 survived for over 2 years, 5 over 3 years and 1 over 4 years. Most of the short course of disease, no specific clinical symptoms, poor treatment. Conclusion The incidence of colorectal cancer in young people is high, the degree of malignancy is high, the rate of misdiagnosis and misdiagnosis is high, and the cure rate and the 5-year survival rate are low. The key to improve the survival rate of colorectal cancer in young people lies in the early diagnosis, only early detection, early diagnosis, timely and reasonable treatment can improve the curative effect.