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性腺轴病变可引起青春发育异常,但非性腺轴的内分泌疾病,也可由于直接或间接的影响引起青春发育异常,下面就最常见的进行讨论。1先天性肾上腺皮质增生症(CAH)不同类型的CAH均伴肾上腺皮质的雄激素合成过多或缺乏。其中发生高雄激素血症的类型主要为21-羟化酶和11-羟化酶缺陷。2
Gonadal axis lesions can cause abnormal puberty, but the non-gonadal axis of endocrine diseases, but also can be due to direct or indirect effects caused by abnormal puberty, the following is the most common discussion. 1 congenital adrenal hyperplasia (CAH) different types of CAH are accompanied by excessive or lack of adrenal cortex synthesis of androgens. Among the types of hyperandrogenism occurring are 21-hydroxylase and 11-hydroxylase deficiency. 2