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目的研究高血压合并心力衰竭与去甲肾上腺素转运体(SLC6A2)基因启动子3、2多态性及相关易感因素。方法选择176例高血压合并心力衰竭的汉族患者(心衰组),同期选择与之按性别、年龄相差±4岁、居住地相匹配的汉族心功能正常的高血压患者176例(高血压组)和血压、心功能正常者176例(对照组)。应用PCR-RFLP检测SLC6A2基因启动子3、2多态性。logistic回归分析易感因素。结果心衰组SLC6A2启动子3-AG/GG基因型频率(41.48%)高于高血压组(26.70%)和对照组(22.16%),差异有统计学意义(P<0.01),3组SLC6A2基因启动子2的GG、GC和CC基因型分布差异无统计学意义(P>0.05)。logistic回归以高血压组为参照系,高血压等级、吸烟、血糖升高、肾功能减退、血红蛋白下降、SLC6A2基因启动子3-AG/GG为易感因素,其中SLC6A2基因启动子3-AG/GG的OR值2.106,95%CI:1.237～3.587,P=0.006。结论老年高血压合并心力衰竭有多种易感因素,应加强对易感因素的控制;携带SLC6A2基因启动子3-AG/GG型者可能是其分子遗传学基础之一。
Objective To investigate the polymorphisms of 3, 2 and related susceptibility factors of hypertension in patients with heart failure and norepinephrine transporter (SLC6A2) gene. Methods One hundred and seventy-six hypertensive patients with heart failure (heart failure group) were enrolled in this study. One hundred and sixty-six hypertensive patients with normal cardiac function in Han nationality (age, ) And blood pressure, normal heart function in 176 cases (control group). SLC6A2 gene promoter 3,2 polymorphism was detected by PCR-RFLP. Logistic regression analysis of susceptibility factors. Results The frequency of 3-AG / GG genotype of SLC6A2 promoter in heart failure group was higher than that in hypertension group (26.70%) and control group (22.16%) (P <0.01). The frequency of SLC6A2 There was no significant difference in the distribution of GG, GC and CC between gene promoter 2 (P> 0.05). In the logistic regression model, the SLC6A2 gene promoter 3-AG / GG was used as a susceptible factor in the hypertensive group, including hypertension, smoking, hyperglycemia, renal dysfunction and hemoglobin. SLC6A2 promoter 3-AG / The OR for GG was 2.106, 95% CI: 1.237-3.587, P = 0.006. Conclusions There are many susceptibility factors for senile hypertension complicating heart failure, and the control of susceptibility factors should be strengthened. The 3-AG / GG type SLC6A2 promoter may be one of the molecular genetic basis.