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目的 探讨北京地区汉族人群中己糖激酶Ⅱ (HKⅡ )基因Glu 14 2His多态性与 2型糖尿病的相关性。方法 采用聚合酶链反应 -寡核苷酸连接测定方法对北京地区 10 2对病例 -对照配偶对进行HKⅡ基因Glu 14 2His多态性基因型检测。结果 病例组和对照组共 2 0 4例样本中均未发现HKⅡ基因Glu 14 2His突变。结论 在北京地区汉族人群中HKⅡ基因Glu 14 2His多态性对 2型糖尿病的发生可能影响不大
Objective To investigate the association between Glu 14 2His polymorphism of hexokinase Ⅱ (HK Ⅱ) gene and type 2 diabetes among Han nationality in Beijing. Methods Polymerase chain reaction - oligonucleotide ligation assay was used to detect the genotypes of Glu Ⅱ 2His polymorphism of HK Ⅱ gene in 102 cases in Beijing. Results No mutation of Glu 14 2His gene was found in 204 cases in both cases and controls. Conclusions The polymorphism of Glu Ⅱ 2His gene of HKⅡ may have little effect on the occurrence of type 2 diabetes in Han population of Beijing