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目的:探讨呼吸机相关性肺炎(VAP)的常见病原菌并分析其耐药性,为临床治疗提供依据。方法:选取我院收治的135例VAP患者的临床资料,分析其病原菌分布以及抗菌药物的耐药性。结果:135例患者中共分离出183株病原菌,其中革兰氏阴性菌135株(占73.77%),革兰氏阳性细菌33株(占18.03%),真菌15株(占8.20%)。革兰氏阴性菌主要为鲍曼不动杆菌,占35.52%,革兰氏阳性细菌主要为金黄色葡萄球菌,占9.84%,革兰阳性菌无一对万古霉素耐药,除了米诺环素总耐药率为42.42%外,其余病原菌对于常用的药物总耐药率均大于60.0%,革兰阴性菌普遍存在多药耐药现象。结论:引起VAP患者感染的主要致病菌为革兰阴性菌群,且存在严重的多重耐药现象,在临床上应加强对VAP疾病的预防和控制,合理应用抗菌药物。
Objective: To investigate the common pathogens of ventilator-associated pneumonia (VAP) and analyze their drug resistance, so as to provide the basis for clinical treatment. Methods: The clinical data of 135 patients with VAP treated in our hospital were selected to analyze the distribution of pathogens and their antibiotic resistance. Results: A total of 183 pathogens were isolated from 135 patients, of which 135 Gram-negative bacteria (73.77%), 33 Gram-positive bacteria (18.03%) and 15 fungi (8.20%). Gram-negative bacteria mainly Acinetobacter baumannii, accounting for 35.52%, Gram-positive bacteria mainly Staphylococcus aureus, accounting for 9.84%, Gram-positive bacteria without vancomycin resistance, except for Minocycline Total drug resistance rate of 42.42%, the remaining pathogens for the commonly used drugs total resistance rates were greater than 60.0%, Gram-negative bacteria widespread multi-drug resistance phenomenon. CONCLUSION: The main pathogens causing VAP infection are Gram-negative bacteria, and there is a serious multi-drug resistance phenomenon. Therefore, the prevention and control of VAP diseases should be strengthened clinically and antimicrobial agents should be rationally applied.